When I open some cell again every time, I have to adjust the toolbar buttons the way I want, after I close window and open some cell again, I have to do it over again, in layout and in schematic.
Is there any way I can have those toolbar buttons layout saved, and stay fixed no matter which cells I open?
Yes, save the workspace. Either use the Save icon on the Workspaces toolbar, or Window->Workspaces->Save As.
You can then either pick that workspace when you want (from the toolbar or Window->Workspaces menu), or you can set a workspace as default (again from the Window->Workspaces menu).