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Only RHEL (4,5) and SLES (10,11) are officially supported with, say, IC614 so one of these would be your best bet. I've heard that CentOS is essentially the same as RedHat, but if you are having issues with RH then CentOS might be the same? I've also heard of Scientific Linux being used and Ubuntu being tried, but I thought there were issues with the latter and neither are supported officially. If you are using an older version of IC61x than IC614 then you might want to visit the Cadence Online Support page and look at Resources -> Computing Platforms -> Supported Platform Matrix for Cadence Applications
Regards,
Lawrence.