To improve PPA on the layout

Hi,
this is quite a general question and its hard to cover in a forum post, so I my comment is just an incomplete list of general considerations.

Always use the latest available tool version to benefit from algorithm improvements.
You can try incremental optimization to get some improvements in timing and power, but you should not expect miracles. Without a qualitative change in the conditions, you just give more iterations to the optimizer to get some marginal improvements of the design.

The following article has some good hints on what to look for and identify weaknesses in your design to improve PPA: PPA (Power Performance Area) Push: Tips & Tricks

If you are not using physically driven synthesis, you should consider this: Introduction to Genus Synthesis iSpatial Flow

If your design contains many macros and the floorplanning is challenging, also try the Mixed Placer Flow – Concurrent Placement of Macros and Standard Cells. This however requires a GigaPlace_GXL license.

In the last years Cadence is working on Machine learning algorithms, you can refer to the following white paper for an intro: How Machine Learning (ML) Enables Cadence Digital Tools to Deliver Better PPA

- Dimo